A comprehensive search strategy was planned and, accordingly, researchers analyzed three electronic databases including Medline, Embase, and Cochrane CENTRAL with no language and time restrictions to find the relevant literature. The team also conducted hand searches of the relevant articles to retrieve other possible studies.
Both parallel and split-mouth RCTs with a minimum follow-up period of two years were included. Non-randomized studies were also selected.
Data extraction and synthesis
Data about study characteristics, demographic and clinical parameters, assessed outcome, outcome assessment methods etc. were retrieved by two independent authors. Network meta-analysis (NMA) was carried for two different outcomes viz caries increment and caries incidence. For the purpose of NMA, standardized mean difference (SMD) was calculated for analyzing the continuous outcome (caries increment) while Odds ratio was used for dichotomous outcome (caries incidence at individual level).
A total of 3,807 publication were retrieved and after sifting 33 RCTs and other quasi-randomized/ non-randomized studies were selected for this NMA. Network diagrams were created and two NMAs were carried; one for caries increment and another for caries incidence.
A total of 18 preventive agents were explored for caries increment and amongst these, only fluoride-foam and fluoride-salt exhibited significant better prevention than the control; with SMD and confidence interval values of 0.69 (0.32–1.06) and 0.66 (0.13–1.20) respectively.
While for caries incidence outcome 11 preventive agents could be included out of which, probiotic-milk + LowF toothpaste, fluoride-foam, fluoride-varnish, and FV + HFTP exhibited significant higher odds of caries prevention; and the odds ratio with 95% confidence intervals were 0.34 (CI = 0.15–0.77), 0.48 (CI = 0.37–0.63), 0.63 (CI = 0.48–0.81), and 0.73 (CI = 0.57–0.93) respectively. SUCRA rankings were also obtained for both the outcomes.
Fluoride preparations, namely fluoride-foam (FF), fluoride-salt (FS) and probiotic milk+ low-F toothpaste (PMLFTP), fluoride-varnish (FV) and fluoride-varnish+ high-F toothpaste (FVHFTP) were found to be effective in preventing early childhood caries.
Gugnani, N., Gugnani, S. "Which of the preventive agents perform best for prevention of early childhood caries?" Evid Based Dent 24, 61–63 (2023). https://doi.org/10.1038/s41432-023-00882-8
News 15 September 2023
The global oral care market has experienced substantial growth, with an impressive increase to $45 billion in 2023.
News 12 September 2023
Designed by dentist Dr. Chrystle Cu, Cocoshine is a 4-in-1 powerhouse for your pearly whites that's packed with nano-hydroxyapatite (n-HA), a fluoride alternative.
Oral Hygiene & Prevention 07 September 2023
By Ingrid Kesa
Brushing our teeth is not usually something held in the same reverence as a face mask or soaking in the bath, but with the right tools and attention to detail it can be just as pleasing.
Nov. 30-Dec. 2, Chicago
The 2023 Dental Implant Conference offers an intensive educational program of innovative techniques and procedures for the entire implant team, presented by an internationally renowned faculty of...
Due to high demand, applications have opened early for Glidewell’s 2024 Guiding Leaders program. Returning for its fourth year, Guiding Leaders is an in-person business and leadership development...
If there’s one word that encapsulates Lauren Chapman’s adult life, it’s leader. From captain of the cheerleading team as a Penn State undergrad, to serving as a Surface Warfare Officer in the...
Clinux CAD, the world’s first cloud-based CAD software designed for dentists, is proud to announce three innovations, expanding its range of possibilities for customers.