HOME - Clinical cases - Oral Hygiene & Prevention
14 September 2023

Bypass gastroplasty impacts oral health, salivary inflammatory biomarkers, and microbiota


Knowledge about the impact of gastroplasty on oral health and salivary biomarkers is limited. The aim was to prospectively evaluate oral health status, salivary inflammatory markers, and microbiota in patients undergoing gastroplasty compared with a control group undergoing a dietary program.

Materials and methods

Forty participants with obesity class II/III were included (20 individuals in each sex-matched group; 23–44 years). Dental status, salivary flow, buffering capacity, inflammatory cytokines, and uric acid were assessed. Salivary microbiological analysis (16S-rRNA sequencing) assessed the abundance of genus, species, and alpha diversity. Cluster analysis and mixed-model ANOVA were applied.


Oral health status, waist-to-hip ratio, and salivary alpha diversity were associated at baseline. A subtle improvement in food consumption markers was observed, although caries activity increased in both groups, and the gastroplasty group showed worse periodontal status after three months. IFNγ and IL10 levels decreased in the gastroplasty group at 3 months, while a decrease was observed in the control group at 6 months; IL6 decreased in both groups (p < 0.001). Salivary flow and buffering capacity did not change. Significant changes in Prevotella nigrescens and Porphyromonas endodontalis abundance were observed in both groups, while alpha diversity (Sobs, Chao1, Ace, Shannon, and Simpson) increased in the gastroplasty group.


Both interventions changed in different degrees the salivary inflammatory biomarkers and microbiota but did not improve the periodontal status after 6 months.

Clinical relevance

Although the observed discrete improvement in dietary habits, caries activity increased with no clinical improvement in the periodontal status, emphasizing the need of oral health monitoring during obesity treatment.

Ribeiro, A.S.P., Marquezin, M.C.S., Pacheco, E.R.P. et al. "Bypass gastroplasty impacts oral health, salivary inflammatory biomarkers, and microbiota: a controlled study." Clin Oral Invest 27, 4735–4746 (2023). https://doi.org/10.1007/s00784-023-05101-3

Related articles

The World Health Organization member states proposed a comprehensive “Global Strategy on Oral Health,” which includes achieving universal oral health coverage by 2030. Challenges and barriers,...

North America should account for 33% of the global market during the forecast period. In this region, the market is driven by rising awareness of the importance of oral health, technological...

P&G brands Crest and Oral-B are donating oral hygiene kits including a smart electric toothbrush to all patients receiving implant therapy at the OCC. The donation will help these patients maintain...

Oral health and systemic health are strongly linked to lifestyles which, if not correct, can increase the risk of periodontal and systemic diseases. ...

Researchers assessed the effects of the pandemic on oral health care provided from July 2020 through December 2021 using national claims data.

Read more

Many qualifying people rely on Medicare fee-for-service for their health care insurance, although it rarely provides coverage for oral health care services.

Japan's universal health insurance covers a wide range of dental treatments, and the co-payment rates differ by age. Researchers investigated whether the inequality in gingival bleeding and dental...

Editorials     22 September 2023

From the bear to the bull market

Since the road to returning to a bull market seems to be long, it is useful to prepare properly and get the right equipment, just like when facing a long journey. 

The new software aims to streamline the guided surgery workflow and provide dentists with a comprehensive guided surgery solution.

USA     21 September 2023 - 23 September 2023

Ohio Dental Association 2023 Annual Session

September 21-23, Columbus

The Ohio Dental Association's Annual Session will offer continuing education (CE) opportunities for all members of the dental team, an expansive Exhibit Hall and social events. The session will be...



Most popular