Objectives
Knowledge about the impact of gastroplasty on oral health and salivary biomarkers is limited. The aim was to prospectively evaluate oral health status, salivary inflammatory markers, and microbiota in patients undergoing gastroplasty compared with a control group undergoing a dietary program.
Materials and methods
Forty participants with obesity class II/III were included (20 individuals in each sex-matched group; 23–44 years). Dental status, salivary flow, buffering capacity, inflammatory cytokines, and uric acid were assessed. Salivary microbiological analysis (16S-rRNA sequencing) assessed the abundance of genus, species, and alpha diversity. Cluster analysis and mixed-model ANOVA were applied.
Results
Oral health status, waist-to-hip ratio, and salivary alpha diversity were associated at baseline. A subtle improvement in food consumption markers was observed, although caries activity increased in both groups, and the gastroplasty group showed worse periodontal status after three months. IFNγ and IL10 levels decreased in the gastroplasty group at 3 months, while a decrease was observed in the control group at 6 months; IL6 decreased in both groups (p < 0.001). Salivary flow and buffering capacity did not change. Significant changes in Prevotella nigrescens and Porphyromonas endodontalis abundance were observed in both groups, while alpha diversity (Sobs, Chao1, Ace, Shannon, and Simpson) increased in the gastroplasty group.
Conclusions
Both interventions changed in different degrees the salivary inflammatory biomarkers and microbiota but did not improve the periodontal status after 6 months.
Clinical relevance
Although the observed discrete improvement in dietary habits, caries activity increased with no clinical improvement in the periodontal status, emphasizing the need of oral health monitoring during obesity treatment.
Ribeiro, A.S.P., Marquezin, M.C.S., Pacheco, E.R.P. et al. "Bypass gastroplasty impacts oral health, salivary inflammatory biomarkers, and microbiota: a controlled study." Clin Oral Invest 27, 4735–4746 (2023). https://doi.org/10.1007/s00784-023-05101-3
Editorials 22 April 2024
Center for Integrative Global Oral Health Brings Together Global Leaders to Advance Health Advocacy
Penn Dental Medicine’s Center for Integrative Global Oral Health (CIGOH) recently convened its Global Oral Health Forum II: Evidence to Advocacy, bringing together global leaders in health policy...
For the past 40 years, Research Day at Adams School of Dentistry has focused on highlighting innovations and insights into oral health care as well as the dedicated researchers who ask questions and...
The evidence on the association between oral health and mortality is inconclusive and few studies have accounted for nonrandom selection bias in estimating their relationship.
Editorials 25 March 2024
Study Shows Correlation Between Self-Reported Oral Health and Systemic Health Outcomes
Looking at multiple dental health conditions and behaviors paints a clearer picture of long-term health and mortality.
News 21 March 2024
Today, on World Oral Health Day, the Delta Dental Institute continued its commitment to diversifying the oral health workforce and promoting health equity by announcing that its Oral Health Diversity...
Editorials 22 April 2024
If there were an indicator for change in music, this would be off the charts if it wanted to measure how many and what changes Miles Davis has made since, at eighteen, he was enlisted, almost by...
Editorials 22 April 2024
Center for Integrative Global Oral Health Brings Together Global Leaders to Advance Health Advocacy
Penn Dental Medicine’s Center for Integrative Global Oral Health (CIGOH) recently convened its Global Oral Health Forum II: Evidence to Advocacy, bringing together global leaders in health policy...
News 22 April 2024
Synchrony Expands Dental Payment Offerings with Adit Practice Management Software Partnership
Synchrony, a consumer financial services company, announced a new partnership with Adit, an industry leading dental practice management software provider. Increasingly, dentists are looking for...
We are thrilled to announce that Mary Beth Kirkpatrick, celebrated consultant and founder of Gaidge, has been honored with the 2024 Outstanding Contribution Award by the American Association of...
KLOwen Orthodontics continues to lead innovation in the orthodontic industry by launching at AAO, the only custom metal self-ligating (SL) solution available and a 2024 Ortho Innovator Honorable...