HOME - Clinical cases - Periodontology
19 July 2021

Evaluation of the efficacy of a new natural gel in non-surgical periodontal therapy

Authors: Giordano


The aim of this experimental in vivo research was to evaluate the efficacy of a new periodontal, topic, and natural gel (mainly made by flowers and fruits sodium bicarbonate and hyaluronic acid) as a substitute of Chlorhexidine operation, without the well-known side effects connected to her. The primary hypothesis is to test that the new natural gel can reduce significantly Bleeding on the Probing index, Plaque index, and Pocket depth index after non-surgical periodontal therapy, if compared to Chlorhexidine and a control group. 


30 patients have been selected according to the following inclusion criteria: 18-70 years old, periodontal pockets greater than 3mm, good compliance, and collaboration. The collected indexes were: Full Mouth Plaque Score, Full Mouth Bleeding Score, and Probing Pocket Depth. 30 patients have been divided into 3 groups: at T0 a collection of the indexes and professional dental hygiene have been conducted for each group. At T1 group C patients (Control group) had a Scaling and Roots planning treatment. Group A patients (Chlorhexidine group) had both an SRP treatment and the administration of periodontal gel Curasept Chlorhexidine 1% [Curasept S.p.A-Saronno (VA), Italy] into pockets. Group B patients (natural gel group) had both an SRP treatment and the administration of periodontal gel Klirich Pro [Itena Clinical-Villeponte, France] into pockets. Patients of groups A and B have been instructed to use their respective gel (Curasept Gel 1% for group A and Klirich Home Gel for group B) in the following 10 days after the treatment. After 40 days (T2) a check has been carried out, in which we have collected indexes, and eventually gel of groups A and B have been administered. Finally, 3 months after the check, indexes have been collected again and professional dental hygiene has been conducted.


The Full Mouth Plaque Score reduction of each group is Group A: 36%; Group B 41.3 %; group C: 12.9%.  The greater reduction of FMPS is in group B, followed by group A. Group C shows a significantly lower reduction of the index. Taking into consideration the Full Mouth Bleeding Score reduction: group A: 34.2%, Group B: 51%. Group C: 19%. Even then, group A and B have a significantly lower reduction if compared with group C. The median value of Probing Pocket Depth shows a reduction of 1.1 mm in group A and 0.9 in group B. Indeed, group C shows a reduction of 0.4 mm. 


Statistical analysis demonstrates that the use of the natural gel, combined with non-surgical periodontal therapy, has a statistically significant role (P<0.05) in the indexes reduction. Within the limits of this research, because of the limited number of patients and the follow-up, we can conclude that this natural gel shows comparable results to the group treated with Chlorhexidine gel, without showing side effects of pigmentation and dysgeusia.


Results gained from this experimental study underline the growing trend of using the natural gel as an adjuvant of non-surgical periodontal therapy. Further studies should be conducted in order to confirm efficacy (taking into account FMPS, FMBS, PPD indexes) and to exclude potential side effects. 

Related articles

Prosthetic rehabilitation using fixed dental prostheses improves the quality of life and oral health of patients who need replacement of missing teeth or just restoration of teeth.  In order to...

As life expectancy continues, an increase in periodontal disease is also expected. In old patients, the concept of shortened or reduced dental arch (SDA) could offer options for solving these...

Periodontal disease is an inflammatory disease and if  untreated can lead to tooth loss, compromising chewing and aesthetic function.Periodontal disease causes a local oral inflammatory response...

Periodontitis is a chronic inflammatory disease caused by a dysbiotic biofilm in genetically predisposed hosts. It is the sixth most frequent disease in the world, affecting 10% of the population in...

Periodontal disease is one of the most common chronic inflammatory diseases around the world. If untreated, it may lead to loss of tooth-bearing tissue, apical migration of the junctional epithelium,...

Read more

Mergers and acquisition firm, Viper Equity Partners, has created a new program, The Phoenix, to speed closure of sales of dental practices. Viper's fund aims to close acquisitions in less than 90...

Authors: Marco Campana, Mariani Umberto, Valeria Martini, Riccardo Bonacina, Sonzogni Aurelio

The Objectives of this work are to propose a literature review from 2008 up to 2018 about oral manifestations of sarcoidosis and scar-sarcoidosis and to introduce a rare case of a primary intraoral...

The zirconia dental materials market is projected to hit $364.3 million by 2028, a market research company. The increase marks a 7.8% CAGR from this year to 2028. Growth in the segment is...

Editorials     04 August 2021

Editorial summer 2021

It has been approximately one and a half year since the Covid-19 pandemic changed the course of the world and influenced the lifestyle of many people, regardless of their background and profession....

Authors: Emanuela Serritella, Paola Di Giacomo, Chiara Vompi, Gianni Falisi, Carlo Di Paolo

Aim: This study aims to compare the epidemiological data of three cohorts of dysfunctional patients attending to the Clinical Gnathology Service of “Policlinico Umberto I University Hospital...


Most popular




Copyright © 2021 - All Rights Reserved
ISSN 2767-1178